Level of evidence

S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, benign bone tumor defect surgery, spine surgery, and the treatment of osteomyelitis. In a recent review van Gestel et al. demonstrated excellent clinical results is various clinical indications [6]. This was also published by several authors in different clinical indications [7-12].